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This review highlights the evidence that (i) the pathogen's broad host range and stress-associated aggressiveness complicate management, (ii) sesame resistance is predominantly polygenic/quantitative, making phenotypic selection alone slow and environmentally confounded, and (iii) progress has been limited by narrow cultivated diversity, variable screening methods, and incomplete functional understanding of resistance pathways

Melanotan II (sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH) is a synthetic cyclic analogue of -MSH (-melanocyte-stimulating hormone) developed at the University of Arizona in the 1980s

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