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Many cancers like prostate cancer and cancers of the spinal cord itself result in the narrowing of the passageways in the vertebral column and cause spinal cord or nerve root compression

Increasing growth hormone and IGF-1 levels may carry potential risks, including worsening insulin resistance in some individuals and, theoretically, stimulating the growth of existing cancers

avoid in patients with evidence of iron overload

Body weight considerations Unlike some peptides where dosing scales with body weight, cagrilintide uses fixed doses across weight categories in clinical trials