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After 24 weeks treatment, there were no significant differences between the groups for the primary endpoint of change in left ventricular ejection fraction, regardless of whether the patients had comorbid diabetes or not

How long to stay on medication: This ties into dosage as well because after reaching the max dose, you might wonder, How long do I continue? Current FDA approvals consider these meds for long-term, chronic use for weight management, not just a quick fix [utswmed.org]

Despite strong biological rationale and epidemiologic data, oral semaglutide did not demonstrate clinical benefit in the EVOKE and EVOKE+ trials, underscoring the complexity of translating metabolic repair into cognitive outcomes in established Alzheimers disease

The bigger the difference the more stress will be on the listeners ear the lesser the difference the more comfortable and enjoyable the experience for the listener is