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When sun damage is significant, we almost always recommend a biostimulatory filler be used with laser or ultrasound treatment, as this provides the greatest improvement in skin quality

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It is instructive that the 2021 EUGOGO guidelines include Se supplementation in the treatment regimen for mild GO, recommending a 6-month treatment with Se preparations for patients with mild GO of short duration to prevent the progression to more severe forms of GO (34)