Y., Kaczmarek, A., Hoque, A., Davie, E., Ngoei, K
The administration of System X c inhibitors can deplete intracellular cysteine, reduce GSH concentration, trigger OS, and increase cell sensitivity to ferroptosis ( Small molecule erastin can directly and selectively target and inhibit the System X c , and irreversibly bind to and inactivate XCT, leading to continuous disorder of cystine uptake, a decrease in cellular antioxidant capacity, and eventually ROS accumulation and ferroptosis (Sato et al., 2018
If tolerance is good and no adverse effects occur, increase to 75mg daily, often split into two doses of approximately 37.5mg each
Note: In this article, the terms GLP-1 agonists and GLP-1 medications include Zepbound and Mounjaro