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The use of NAC can help improve the likelihood of success of a standard course of cortisone in the treatment of acute hearing loss: After six months, the combination therapy group showed a hearing threshold improvement of 26 decibels compared to only 15 decibels for the cortisone group

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We report an additional function for PPP-derived NADPH, as it is also necessary to confine ROS generated during oxidative protein folding in the ER