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Over longer time periods, namely after 4-OHT induction at E13.5 or E15.5, GFP-negative ECs replace the Bmx-CreERT2 -labeled GFP + cells in submucosal and smaller (distal) mesenteric arteries so that recombined ECs reside only in the larger caliber arteries (Supplementary Fig

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No significant difference in the prevalence of symptoms was found between participants with MMA levels 400 nmol/l (n = 60) and those whose levels were 600 nmol/l showed some improvement in neurological symptoms (Hvas, 2001b)

Questions remain around dosing, safety, and realistic expectations for BPC-157 therapy