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Ribeil et al., 2017)

The REWIND trial with dulaglutide and SUSTAIN-6 with semaglutide also demonstrated cardiovascular benefits

Protein target: 0.7-1.0g per pound of ideal body weight

The reason is that only one nucleotide substitution is needed relative to the subtype 1a sequence to generate this variant, whereas two substitutions are needed relative to the 1b sequence (codon usage bias)