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According to clinicians, sublingual administration bypasses both the gut and the liver, allowing glutathione to enter the bloodstream in its reduced (active) form, boosting the ratio of GSH to GSSG by 230 per cent, whereas oral glutathione supplementation is either reduced into simple amino acids during digestion or oxidised and hence, no longer stays active when swallowed

doi: 10.3389/fbioe.2021.677576 Received 07 March 2021 Accepted 12 April 2021 Published 29 April 2021 Volume 9 - 2021 Edited by Zhen Li, AO Research Institute, Switzerland Reviewed by Guangli Suo, Suzhou Institute of Nano-tech and Nano-bionics (CAS), China