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If a patient already has slow stomach emptying, known as gastroparesis, a GLP or GLP/GIP should likely be avoided, as this condition will only worsen when the medication is started, often leading to intolerable side effects

The use of NAR to ameliorate the intestinal Ca 2+ transport under oxidant conditions associated with different pathologies holds a remarkable potential, but there are some obstacles in NAR clinical translation related to the extensive in vivo metabolism, low bioavailability and irregular absorption[74]

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