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No birth defect pattern has been reported in humans exposed to semaglutide during pregnancy, but the number of documented exposures remains small

Similarly, a small pilot study showed that combining liraglutide with Metformin before conception significantly increased in vitro fertilization pregnancy rates compared to Metformin alone (109)

Accordingly, we could only detect a tendency for reduced SPHKAP mRNA levels in whole islets transduced with SPHKAP versus Control shRNA lentiviruses (Supplementary Fig