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Direct stimulation of these central receptors can trigger nausea independently of gastric effects

When pomegranates are consumed the ellagitannins are hydrolyzed, releasing ellagic acid, which is then converted to 3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one derivatives (called urolithin A and urolithin B) by gut microflora

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Studies comparing oral glucose and equivalent amounts of intravenous glucose have found that oral glucose intake led to a greater than 50% increase in insulin response, which was attributed to the incretin effect [89]