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The absolute risk increase for diabetic retinopathy complications was greater among patients with a history of diabetic retinopathy at baseline (semaglutide 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide 0.7%, placebo 0.4%)

Although these mechanisms mainly control the progression of the cell cycle (26), recent studies have reported important roles for the E2F1-pRb-CDK4 pathway beyond the sole regulation of cell proliferation (27, 28)