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Note, the similar beneficial results of BPC 157 therapy obtained after different application routes are consistent with the high applicability of the agent, whatever route of the application [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40] overwhelms limited applicability and activity to prophylactic application only of standard cytoprotective agents [41,42,43,44,45,46,47,48,49]

This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)

Ca 2+ signaling-associated phospholipid membrane scrambling is mediated by upregulation of scramblase and downregulation of flippase, which consequently leads towards the observed asymmetry with phosphatidylserine externalization [186]