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A "thrifty" genotype was defined as "being efficient in the intake and/or utilization of food." Thus, during famines, individuals with a "thrifty" genotype would have a survival advantage because they relied on larger, previously stored energy to maintain homeostasis, whereas those without "thrifty" genotypes would be at a disadvantage and less likely to survive (4)

Food and Drug Administration (FDA) for any medical use, including weight management

GLP-1 medications reduce appetite and slow gastric emptying, which often creates a significant calorie deficit in the early weeks of treatment

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