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These mutations can alter the enzymes effectiveness, potentially leading to health issues, earlier for some and over time for others

Simultaneously, they suppress glucagon secretion (which normally raises blood glucose), slow gastric emptying to reduce post-meal glucose spikes, and act on appetite centres in the brain to promote satiety and reduce food intake

Furthermore, metformin treatment alone was demonstrated to significantly induce cell death in both HCT116 and SW837 cells, although this effect was more pronounced in HCT116 cells, supporting previous studies (33, 63)