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Platelet activation triggers further leukocyte activation and promote RBC adhesion to an exposed endothelium ( ex vivo studies, and was well tolerated by patients, but on a 24-month follow up, patients on the treatment arm failed to show reduction in the frequency of VOC (Kanter et al., 2019) (ClinicalTrials.gov identifier: NCT02482298)

[1] Serious gastrointestinal events were not prominently reported in the available phase 2 data, though the limited duration and sample size of phase 2 studies mean that longer-term phase 3 data will provide a more complete safety picture

Oxidative stress-induced cellular senescence: is labile iron the connecting link

Affordable self-pay options for compounded semaglutide and compounded tirzepatide may also be available for eligible patients