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Duggan C, Wang C-Y, Neuhouser ML, Xiao L, Smith AW, Reding KW, et al

He was drawn to research obesity through his work on diabetes

In the sections that follow, we build on this conceptual framework to examine how major proteostasis machineries contribute to cellular and organ-level resilience and how their failure drives pathology across cardiovascular, cancer, metabolic, neurodegenerative and autoimmune disorders and highlight therapeutic strategies aimed at reinforcing proteostasis resilience