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The agencys September budget request to the governors office attributed the increased use of expensive weight-loss meds with brand names like Wegovy, Zepbound and Saxenda to an explosive rise in demand

Underlying medical conditions: Certain conditions can blunt weight loss responses, including hypothyroidism (a thyroid function test is advisable if not recently checked), Cushing's syndrome or exogenous corticosteroid use, polycystic ovary syndrome (PCOS), and obstructive sleep apnoea (OSA)

Detailed management strategies appear in the semaglutide constipation treatment and tirzepatide constipation treatment guides

However, metformin-induced enhancement of incretin action does not appear to be a major mechanism by which metformin lowers blood glucose