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In mouse models that mimicked RBC transfusion and clearance in a clinical setting, the RBC phagocytosis of splenic RPMs increased after rapid transfusion of large amounts of RBCs, but the increase in HO-1 was still insufficient to prevent ferroptosis of splenic RPMs triggered by massive RBC phagocytosis (43)

doi:10.1001/archderm.120.9.1212

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