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Subsequently, fluid overload, a key feature of HF, is reduced.25,26 Effects on Epicardial Adipose Tissue GLP1-RAs decrease the volume of epicardial adipose tissue, which is often elevated in HFpEF and is a source of proinflammatory cytokines and adipokines.6 Neurohormonal Mechanisms GLP-1RAs may modulate the activity of the autonomic nervous system by shifting the balance away from sympathetic overactivation towards parasympathetic tone.2730 Studies have shown that GLP-1RAs can inhibit carotid body chemoreceptor activity, reducing sympathetic nervous system outflow

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