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Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

The reasons could have been multipronged ranging from toxic accumulation of folate and B12 in patients of diabetic nephropathy with low GFR or competitive inhibition of TMP and TPP transport at the level of RFC1 transporter by high dose folate at key sites such as the kidney and vascular cells thus adversely affecting sharing of thiamine between tissues rich in thiamine and those deficient in it [183]

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