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This is a moderate early-to-mid dose on the standard escalation schedule

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Lilly's LY2409021 showed the same pattern: efficacious glucose lowering, unacceptable hepatic and lipid signals

Lancet 372(9645):12401250 Drucker DJ, Sherman SI, Gorelick FS, Bergenstal RM, Sherwin RS, Buse JB (2010) Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits