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If urine albumin excretion remains abnormal, further therapy (based on individual preferences) with an SGLT2i, nsMRA, and/or GLP1-RA with proven kidney protection will help slow CKD progression and reduce cardiovascular outcomes (Figure 6)

These arent random side effects they stem from the way extreme dietary restriction influences hormonal function

Ongoing investigations continue to examine the peptides mechanisms of action and potential therapeutic applications, though definitive conclusions about its clinical benefits require additional research

most preclinical studies use young adult animals rather than aged subjects with accumulated pathology