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Here, we explore the role of the intestinal barrier in driving systemic inflammation, touching upon on the consequent pathological conditions and the potential gut barrier-targeted therapeutic opportunities following these findings

These hormones are part of the gut-brain axis, and their respective receptors are often present in the periphery as well as in the brain. Elucidating the pathways and processes through which GLP-1 and similar hormones modulate weight loss may allow for the finetuning and evolution of novel therapeutic interventions against obesity, which, if left unchecked, is expected to impact more than half the worlds human population by 2035

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[DOI] [PubMed] [Google Scholar] 93.Aliotta A, et al