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Figure 7: Changes in the levels of A) IL-1-beta, B) TNF-alpha, and C) IL-10 in each of the four different experimental groups included in the first part of the study

The deiodinases DIO1 and DIO2 can activate T4 by transforming it into T3 by removal of the 5-iodine, while DIO1 and DIO3 can prevent T4 from being activated by converting it to the inactive reverse T3 ( Reference Darras and Van Herck 68 ) (Fig

When combined with a short-acting GHRH analog, the resulting model attempts to more closely replicate a physiological pulsatile GH response