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Melanin is the pigment responsible for skin color, and higher melanin levels typically result in a darker complexion

Via its MYST family histone lysine acetyltransferase (HAT) domain, KAT6A has been proposed to acetylate histone H3 at lysine 14 (H3K14) in HEK293T cells (Doyon et al, 2006), H3K9 in mouse embryos (Voss et al, 2009, 2012), and H3K23 in glioblastoma cells (Lv et al, 2017)

Moreover, reduction in intestinal bile acids contributes to the metabolic benefits of bariatric surgery and a bile acid receptor is required to mediate the effects (47, 48)