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No systemic toxicity has been reported in human or animal studies

Several competing risks may hinder the identification of positive results in kidney trials, particularly cardiovascular outcomes

Whether IGF-1 LR3's prolonged receptor occupancy exacerbates this suppression more than native IGF-1 has not been studied directly, but the mechanism predicts a greater effect per unit time of receptor engagement [1, 18]

Participants were divided into four groups based on the PA levels as previously described [14, 29], including inactive (with no moderate- or vigorous-intensity PA), insufficiently active (with total MET being 0 to 600 METs-min), moderate active (total METs being 600 to 3000), and highly active (total METs more than 3000)