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Primary IGF deficiency (PIGFD) is assigned to children exhibiting chronically low levels of IGF-1, despite normal levels of GH and no other underlying causes of poor growth [39]

74, 140, 143, 144, 145, 146, 147, 148 In some models, also non-ketogenic low-CHO diets (1015E% CHO) led to significant tumor growth retardation that was correlated to low blood glucose and insulin levels

Activation of Killer Immunoglobulin-like Receptor (KIR)-DS1 on uNKs by HLA-C2 on trophoblasts stimulates the production of soluble Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and XCL1 from uNKs leading to increased migration of trophoblasts in vitro (52)

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