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System Xc is an antiporter composed of SLC7A11 and SLC3A2, which mediates the cellular uptake of extracellular cystine for GSH synthesis ( 3 Ferroptosis in PCOS 3.1 Core pathophysiological features of PCOS and ferroptosis Ovulatory dysfunction in PCOS often leads to oligomenorrhea or amenorrhea, which reduces iron loss through menstruation

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Functional validation using receptor-deficient models confirms that 3-adrenergic signaling is required for these effects, as disruption of this pathway attenuates peptide-induced lipolysis

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