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The primary mechanisms of action include: Enhancing glucose-dependent insulin secretion from pancreatic beta cells, which helps lower blood glucose levels when they are elevated Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose production [1] [2] Slowing gastric emptying , which moderates the rate at which nutrients enter the bloodstream Promoting satiety through central nervous system pathways, leading to reduced caloric intake [1] [2] These medications are peptide-based (and one fusion protein) and are temperature sensitive

Appetite suppression strengthens noticeably

In addition, Semaglutide, another long-acting GLP-1 RA, has demonstrated superior efficacy in lowering blood glucose levels and reducing body weight compared to placebo or Liraglutide

Most patients can drink alcohol while taking semaglutide