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Additionally, NRF2 activation reduces oxidative stress in HSCs, which is another key driver of the activation and progression of fibrosis

Exenatide, liraglutide, and semaglutide were associated with metabolic and nutritional AEs, and multiple GLP-1 RAs novel AE signals were identified by disproportionate analysis

One possible explanation for such a response is that inhibition of mTORC1 and activation of GCN2 collectively suppresses global translation to conserve nutrients, while selective translation of mRNA such as ATF4 (mediated by increased p-eIF2) activates the expression of AARE genes to mitigate cellular stress

Diabetes, Obesity and Metabolism, 25 (2), 468-478.doi: 10.1111/dom.14890