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No expectation of visible change for several weeks this is the point where most people either commit to the full course or, mistakenly, start checking daily for signs of progress that biologically cannot appear yet

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[2] The MHRA Drug Safety Update (August 2022) advises healthcare professionals to consider testing vitamin B12 levels in patients taking metformin who develop symptoms of neuropathy or anaemia, and to consider periodic monitoring in those at risk of deficiency

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