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Powell et al., compared subglottic aspirates of patients who had been mechanically ventilated for a median of five days to newly intubated patients, identifying significantly higher levels of MUC5B (but not MUC5AC) [74]

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Challenges related to pharmacokinetics, manufacturing, and immunogenicityparticularly when peptide lengths exceed approximately 15 amino acidshave introduced further barriers, impeding progress in the field