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Description

In any case, most side effects were tolerable and tended to get better with time

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For example, TPD uses an event-driven, catalytic mechanism, allowing the compounds to bind anywhere on their target protein, bind less potently than traditional inhibitors, and be used at sub-stoichiometric levels

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Allosteric modulation by PAMs that bind anywhere distinct from the orthosteric site of endogenous ligands and enhance the activity of agonist in an uncompetitive way is an alternative approach to peptide therapy 1922

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