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Under conditions of low glucose, oxidative stress, or inflammation, mitochondria increase production of MOTS-C, which then: Enters the nucleus to modulate transcription of genes associated with antioxidant defenses, such as NRF2 targets

Peptides are short chains of amino acids that act as signaling molecules, helping direct everyday processes such as repair, metabolism, and energy

GLP-1 receptor agonist meds help regulate blood glucose by stimulating insulin secretion when blood sugar levels are high and reducing glucagon release to prevent spikes

Zhang Y, Shimizu H, Siu KL, Mahajan A, Chen JN and Cai H, "NADPH oxidase 4 induces cardiac arrhythmic phenotype in zebrafish", J