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Other contributing factors include: Injection technique errors injecting too quickly, failing to use appropriate technique, or withdrawing the needle too soon Injection comfort using medication directly from the refrigerator may cause more discomfort Individual immune responses mild inflammatory reactions to the medication or excipients Inadequate site rotation using the same anatomical area repeatedly Sterile inflammatory nodules localised tissue reaction that may persist longer than typical injection site reactions Most injection site lumps are benign and resolve spontaneously within days to weeks

Patients with genetic variants affecting the GLP1R receptor (rs6923761) or MC4R pathway (rs17782313) may experience different tolerability profiles