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Researchers are exploring how to use MSCs to repair tissues such as bone, tendon, ligament, and cartilage.[47] In several early tendon studies, researchers surgically created one-centimeter-long gap defects in rabbit tendons and then implanted composites of stem cells suspended in Type I collagen gel into the injuries.[2,3,15] In one study, MSC treated tendons were twice as strong as untreated tendons after 4, 8, and 12 weeks.[15] The treated tendons also had larger cross-sectional area and better aligned collagen fibers

As inflammation decreases, melanogenesis signalling may also reduce

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