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Ipamorelin is a synthetic pentapeptide belonging to the group of ghrelin mimetics, acting as a selective agonist of the GHS-R1a receptor (Growth Hormone Secretagogue Receptor)

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Consistent with this, use of a reducing source such as -mercaptoethanol allows reversal of xCT-KO phenotype, as it has been reported couple decades ago by Bannai's group ( in vivo can explain the discrepancy with in vitro phenotype