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85 Serial studies from the US and Europe suggest that energy expenditure from physical activity increased between 1981 and 2017, during the onset of the obesity epidemic, while basal metabolic expenditure declined, implicating other factors such as dietary composition that impact metabolic rate

GLP-1 receptors are also widely distributed in the hypothalamus, and their activation enhances satiety, which leads to a decrease in calorie intake and consequently weight reduction [25]

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