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The effects of dietary patterns on health are complex and understanding their mechanisms will be necessary to use diet for the treatment of obesity and other health conditions

No clinically meaningful changes in vital signs or in ECG (including in QTc interval) were observed in patients treated with Januvia

Under pathological conditions, excessive lactate accumulation promotes aberrant lactylation patterns that may drive persistent inflammation, metabolic reprogramming, and neuronal dysfunction by reshaping chromatin accessibility and transcriptional landscapes