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The presence of microplastics may potentially harm the central nervous system by affecting neuronal function and survival through multiple mechanisms, including neuroinflammation, oxidative stress, cytotoxicity, and hormonal disruption (3)

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The most common pathogenic mutation in LRRK2 involves the substitution of glycine (G) with serine (S) at position 2019 (G2019S), which is located within the highly conserved DFG (Asp-Phe-Gly) motif immediately preceding the activation loop of the LRRK2 kinase domain