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The dose escalation approach used in research settings typically follows a structured stepwise pattern: Starting dose: A low dose (e.g., 12 mg once weekly) for the initial weeks Intermediate doses: Gradual increases at protocol-specified intervals Maintenance dose: A target dose determined by tolerability and clinical response It is important to note that, as retatrutide is not yet approved for clinical use in the UK, there is currently no officially recommended dosing regimen for patients outside of clinical trial settings