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FIGURE 3 The functional enrichment analysis of Gene Ontology (GO) by ClueGO revealed that the identified proteins were involved in various crucial biological functions such as chromosome condensation (GO:0030261), hexokinase activity (GO:0004396), nucleosome assembly (GO:0006334), canonical glycolysis (GO:0061621) and NADH regeneration (GO:0006735)

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Broadly speaking, this work signals a shift towards integrating tobacco treatment within chronic disease management frameworks, encouraging clinicians and policymakers to view smoking cessation not as a standalone behavioural goal, but as part of comprehensive cardiometabolic risk reduction strategies embedded within routine care. Tobacco Use: Public Health Threat Tobacco use remains the leading preventable cause of morbidity and mortality worldwide

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