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Nishimura M, Tokoro T, Takatani T et al (2015) Effects of intravenous l-carnitine on myocardial fatty acid imaging in hemodialysis patients: responders or non-responders to l-carnitine

Advise patients to discontinue JANUMET immediately and to promptly notify their healthcare provider if unexplained hyperventilation, myalgias, malaise, unusual somnolence or other nonspecific symptoms occur

For context, in a major semaglutide weight loss study using the 2.4 mg dose (marketed as Wegovy for weight management), average weight loss at 12 weeks was about 9.6% of starting body weight

UKPDS 26: sulphonylurea failure in non-insulin-dependent diabetic patients over six years