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The exact signaling pathway of PPAR in UF has not been clearly characterized despite the fact that PPAR protein isoforms are expressed at higher levels in UF (Tsibris et al., 1999) or a relatively equal level as compared to the normal myometrium ( Apoptosis of uterine leiomyoma cells was also stimulated by the expression of caspase-3, an important mediator for apoptosis, and by caspase-9, an initiator of apoptosis (Yu et al., 2008)

CD19 + pS6RP + Akt + B cells one - way ANOVA p = 0.0084, Sidaks post-hoc test p values corrected for multiple comparisons: B6.TC/Rab4A Q72L (Veh) vs B6.TC/Rab4A Q72L (NAC) p = 0.0156, B6.TC/Rab4A Q72L (Veh) vs B6.TC/Rab4A Q72L (Rapa) p = 0.0110, B6.TC/Rab4A Q72L (Veh) vs B6.TC/Rab4A Q72L -KO (Veh) p = 0.0129

Kidney Int 64(1):281289

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