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When p53 transcriptional activity in response to 5-FU treatment was measured, the mRNA and protein levels of p21, which is a p53 target gene, were decreased in the GST WT -p53-expressing cells

Trends Cell Biol 21:745754

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

500 Additionally, PepGens PGN-EDO51, designed to skip exon 51 in the DMD gene, has shown promising results in Phase I clinical trials and is now in Phase II (NCT06079736)