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That's a reason to keep on top of your nutrition and strength-training while on these drugs, he writes, "especially for older people like me, who are [already] susceptible to muscle loss." There are people who should steer clear of GLP-1 drugs, Kessler notes, including those with a personal or familial history of certain thyroid and endocrine cancers, those with chronic kidney disease, pancreatitis, inflammatory bowel diseases, uncontrolled diarrhea or constipation or gastroparesis, or if you are pregnant

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Also, during STEP 5, a study to assess efficacy of semaglutide with a follow-up of 2 years, there is a post-hoc analysis that demonstrates a better performance in the self-reported Control of Eating Questionnaire(CoEQ) to measure changes in appetite versus placebo, with lower cravings for dairy and starchy foods and less desire for salty and spicy food at short-term (20 weeks) but also as a maintenance therapy at weeks 52 and 104 (178)

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