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The 2025 trials asked something harder: whether the drugs already on the market, at the doses and in the populations studied, can slow human neurodegeneration, and for semaglutide in Alzheimers disease and exenatide in Parkinsons disease, the answer was no

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Liver tissue pathology (HE staining, 100) showed pseudolobules with severe turbidity in the hepatocytes within the pseudolobules and macrovesicular fatty degeneration in some hepatocytes (F1-F2)

Thus, modulating FTH1 levels via upstream regulatory pathways may represent a key therapeutic strategy for HF