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Here, we confirm the GIPR antagonist and GLP-1R agonist activities in cell-based systems and report the ability of AMG 133 to reduce body weight and improve metabolic markers in male obese mice and cynomolgus monkeys

doi: 10.1159/000297775

Studies show: Elevated IL-6 and TNF- Persistent interferon signatures T-cell exhaustion Altered CD4/CD8 ratios Increased autoantibodies, including anti-nuclear antibodies (ANA) and anti-phospholipid antibodies 5 There is also growing evidence of microglial activation in patients with neurocognitive symptoms, suggesting ongoing neuroinflammation

It is important to note that the weight loss benefits observed in clinical trials came in conjunction with diet and exercise regimes